Cell-free or Circulating Tumour DNA (ctDNA)

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  • Cell-free or circulating tumour DNA (ctDNA) is tumor DNA circulating freely in the blood of a cancer patient.
  • Originates from dying tumour cells and can be present in a wide range of cancers but at varying levels and mutant allele fractions.

clinical Utility

  • Qualitative and quantitative testing of circulating cell free DNA (CCFDNA) can be applied for the management of malignant and benign neoplasms.
  • Detecting circulating DNA in cancer patients may help develop a DNA profile for early stage diagnosis in malignancies.
  • To look for resistance mutation T790M in EGFR positive patients.
  • Address the tumor heterogeneity.

Benefits

  • It is non invasive
  • Can be a substitute for primary biopsy in sick patients
  • Repeated blood samples are much easier to obtain